41.   This study examined whether the phospholipid composition of the full thickness gastric mucosa is changed in peptic ulcer disease and gastritis.

42.   We investigated the total phospholipid composition of human gastric mucosa from endoscopic biopsy specimens in patients with peptic ulcer disease or gastritis, and in normal subjects.

43.   More important information about the influence of hereditary factors in ulcer disease has been derived from studies of twins.

44.   A major difficulty in genetic studies of peptic ulcer disease has been the lack of subclinical markers.

45.   Some degree of heterogeneity has already been shown in peptic ulcer disease.

46.   Our recent linkage analysis showed that the PGC gene is closely linked to the HLA cluster which has been investigated to determine the association with peptic ulcer disease.

47.   Several genetic and environmental influences have been proposed to explain the racial and the geographic variability in the incidence of peptic ulcer disease.

48.   Peptic ulcer disease is a multifactorial inheritant disease.

49.   In addition, peptic ulcer disease represents a heterogeneous group of disorders attributable to a variety of genetic and environmental causes.

50.   The finding of enhanced fasting gastrin concentrations in H pylori positive subjects and in duodenal ulcer disease cannot easily be explained.