41.   Eight healthy volunteers considered free from peptic ulcer disease and eight patients with endoscopically proved duodenal ulcer disease were studied.

42.   Twenty healthy white volunteers acted as controls for the intestinal permeability studies.

43.   Similarly, infusion of bile salts into the jejunum or ileum of healthy volunteers slows small intestinal transit and inhibits intestinal myoelectrical activity.

44.   On the other hand, patients complaining of chronic diarrhoea and faecal incontinence had squeeze duration values similar to healthy volunteers, measured with perfused catheters.

45.   Eradication of TH pylori lowered the plasma gastrin in the duodenal ulcer patients to values equivalent to the H pylori negative healthy volunteers.

46.   In healthy volunteers, H pylori state was determined by the C urea breath test.

47.   The median basal acid output was similar in the H pylori negative and positive healthy volunteers.

48.   It was increased in the H pylori positive duodenal ulcer patients, however, compared with both the H pylori negative healthy volunteers and H pylori positive healthy volunteers.

49.   The median pepsin output in the H pylori positive duodenal ulcer patients was higher than both the H pylori positive and negative healthy volunteers.

50.   This study shows that chronic H pylori infection is accompanied by appreciably increased gastric acid output in both healthy volunteers and duodenal ulcer patients.