41.   And the pressure comes amidst a host of changes at the FDA, most notably the departure, slated for March, of commissione David Kessler.

42.   And their offensive line has undergone change at three of five positions because of severe injuries.

43.   And the envelopes contain a fund-raising appeal and survey that mesh with recent Republican attacks on the IRS and calls for change at the agency.

44.   And while Lucent suffered an accelerating financial skid, there has been a change at the top.

45.   Another Republican state chairman, Mike Francis of Louisiana, called outright for change at the top of the party.

46.   Any changes at Prudential will take place at year-end, said Atran, the company spokeswoman.

47.   Any deal involving big changes at BellSouth will have a major impact on Atlanta.

48.   Apple executives say the numbers and the naysayers do not give full credit to the recent changes at Apple.

49.   Apple said marketing chief Guerrino De Luca resigned after only seven months on the job, the latest in a series of executive changes at the struggling computer maker.

50.   As a result, analysts said, they expected little change at Archer Daniels, particularly with Andreas continuing as chairman.