41.   This will mean a big headache for school administrators.

42.   To many of them, genetic engineering increasingly is just a big fat headache.

43.   Trying to pin down just which long-distance company really offers the lowest rate has given more than one consumer a big headache.

44.   Tuesday night, more freedom equaled more production for New York, and one big headache for Boston.

45.   Unfortunately, highly publicized research studies notwithstanding, you may also find that headsets at work can lead to one big headache.

46.   Vending machine operators across Europe are facing a big headache, brought about by the euro.

47.   Vending machine operators across Europe are facing a big headache, brought on by the euro.

48.   We found out that sometimes you have to baby-sit and it was a big headache.

49.   What it got was a big headache.

50.   A big headache is about to go away for thousands of business owners who were worried about huge tax liabilities if they sold out.