21.   There is almost certainly widespread illegal use as well as approved uses.

22.   Whether the technology ever will gain widespread use is uncertain.

23.   Increasingly widespread use probably accentuated a chronic shortage of coin.

24.   Richard Gere gives money to Tibetan refugees, Meryl Streep campaigns against the widespread use of pesticides.

25.   Concern about nephrotoxicity has been the major factor limiting more widespread investigational use of cyclosporin in ulcerative colitis.

26.   Despite the increasingly widespread use of oesophageal manometry, few studies have assessed its benefit to patient management.

27.   We judged this to be a potentially important finding in view of the extremely widespread use of cimetidine.

28.   Similarly, despite widespread clinical use, evidence for sulphasalazine renal toxicity is scanty.

29.   Widespread use of trivalent oral poliovirus vaccine has almost eliminated paralytic poliomyelitis from industrialised countries.

30.   The combination of such marked terms with a widespread use of word play is what we can regard as the typical exploitation of language in the French fabliaux.