21.   The concentrations of urokinase type plasminogen activator in the duodenum resemble the quantities found in normal stomach tissue biopsy specimens.

22.   In colon carcinomas urokinase type plasminogen activator is predominantly found in the inactive proenzyme form, which can be activated in the presence of plasmin.

23.   Plasminogen activator inhibitors also control the activity of both tissue type plasminogen activator and urokinase type plasminogen activator by forming inactive inhibitor enzyme complexes.

24.   Inhibition of the fibrinolytic system takes place at the level of both the plasminogen activators and plasmin.

25.   Several attempts either to increase the efficacy of plasminogen activators or to reduce their clearance have been undertaken.

26.   Murine monoclonal antibodies conjugated with plasminogen activators may be valuable for targeting the therapeutic agent to thrombus.

27.   A thrombus contains both fibrin-rich and platelet-rich material, and targeting of plasminogen activators could be achieved by either antifibrin or antiplatelet monoclonal antibodies.

28.   In summary, several approaches have produced engineered plasminogen activators with an increased thrombolytic potency in experimental animal models.

29.   SIR, -- Ridker and colleagues emphasise the role of endogenous tissue-type plasminogen activator as a risk factor for myocardial infarction.