21.   Lower concentrations of PYY did not significantly inhibit carbachol stimulated motor activity.

22.   Intra-arterial infusion of PYX did not significantly change carbachol stimulated ileal motor activity.

23.   Similarly, infusion of PYX did not prevent bile inhibition of ileal motor activity.

24.   This study showed that luminal infusion of bile and the bile acid TDCA inhibited carbachol stimulated motor activity in isolated segments of rabbit terminal ileum.

25.   This suggested that bile inhibition of ileal motor activity was mediated by a humoral agent from the terminal ileum present in the venous effluent.

26.   In contrast, infusion of taurodeoxycholic acid at these concentrations inhibited ileal motor activity.

27.   These results indicated that bile and TDCA inhibited terminal ileal motor activity by a mechanism that was not mediated by PYY, enteroglucagon, or VIP.

28.   These findings suggested that bile and taurodeoxycholic acid directly inhibited ileal motor activity.

29.   In man, infusion of bile salts into the jejunum at physiological concentrations prolongs small bowel transit time and inhibits intestinal motor activity.

30.   Furthermore, preinfusion of PYX, a specific competitive antagonist of PYY, did not reduce bile inhibition of ileal motor activity.