21.   Cell surface proteins were iodinated by the lactoperoxidase method as described by Hynes and Wyke.

22.   Mucosal appearance was graded from zero to three according to Baron et al, and histological appearance and vascularity scored as described by Powell-Tuck et al.

23.   Lipid vesicles were sized by photon correlation spectroscopy as described by Barenholz et al using a Malvern Autosizer II C.

24.   Excess ATP was destroyed with potato apyrase and labelled, adducted nucleotides were separated by chromatography on PEI cellulose plates as described by Gupta.

25.   Oesophageal manometry was performed as described by Richter et al.

26.   The global rating scale was used as described by Jaeschke.

27.   Results were analysed with the paired t test for crossover trials as described by Hills and Armitage.

28.   In addition, the prognostic correlation with plasminogen activator inhibitor, as described by Hamsten et al in young MI survivors, was not as evident.

29.   Because we had an interest in comparing methodologies, a second, simpler scoring system for clinical severity, as described by Costa et al, was also used.

30.   The test runs described by Erman and Lesser use an island-driving strategy.