21.   Breast cancer was just the tip of the iceberg.

22.   Colorectal carcinoma ranks second only to lung cancer in men and to breast cancer in women in the United States.

23.   Deletion of the gene in breast cancer is associated with reduced patient survival and increased risk of lymph node metastasis.

24.   Not as many as women die of course but men even die of breast cancer.

25.   For instance in nineteen eighty eight more men died from breast cancer in the United States than died from AIDS.

26.   In advanced breast cancer, chemotherapy has been shown to improve both quality of life and conventional endpoints, and in such circumstances treatment can readily be advised.

27.   This has been done in assessment of moderately toxic adjuvant chemotherapy for early breast cancer.

28.   SIR -- Loba highlights the lack of information on the use of hormone replacement treatment in women who have had breast cancer.

29.   To avoid disease activation, we add tamoxifen on the basis that it has proven efficacy in the treatment of breast cancer in premenopausal women.

30.   Thus, it may be possible to design hormone replacement that retains the ability to control menopausal symptoms while protecting against breast cancer.