11.   Monsanto Co., maker of the blockbuster sweetener Nutrasweet, is trying to win government clearance for a next generation calorie-free sugar substitute, the company said.

12.   Now, these age-old, often homemade sugar substitutes have acquired culinary cachet.

13.   Other experiments will attempt to synthesize large protein crystals for the eventual fabrication of cancer-fighting drugs and to produce a new sugar substitute.

14.   The guidelines do not suggest sugar substitutes as an alternative for weight loss.

15.   The recipes provided here focus on sugar substitutes.

16.   Tice also did research on sorbitol, a natural or synthetic crystalline alcohol used as a sugar substitute for people with diabetes.

17.   To keep the calories in check, sweeten with a little sugar substitute instead of sugar.

18.   When the Eisenstadts mixed saccarin with dextrose and other ingredients to make a granulated low-calorie sugar substitute, another coffee revolution was at hand.

19.   Monsanto makes ingredients for agricultural products, pharmaceuticals and foods including the Lasso and Roundup herbicides and the Nutrasweet sugar substitute.

20.   The powder was later found to be a sugar substitute.