11.   To achieve this a set of regulations has been introduced which is having a profound effect on the electrical and electronics sectors.

12.   Yet its timing, duration, scale and outcome were to have a profound effect upon the form that the revolution took.

13.   Yet these elements have had a profound effect on the evolution of the Earth because of their radioactivity.

14.   Computers have had a profound effect on our lives.

15.   His paintings have had a profound effect on her own work.

16.   The book had a profound effect on his impressionable young mind.

17.   The Depression had a profound effect on that generation.

18.   This has had a profound effect on systems analysis and database design.

19.   Selection pressure operates on all stages of life cycles and has profound effects on the physiology and biochemistry of parasites.

20.   The opposition of these two blocs has had a profound effect on the geopolitics of the global system in the second half of the twentieth century.