11.   But gastric metaplasia may also develop as a non-specific response to mucosal injury not associated with acid peptic damage.

12.   Such alkaline secretion may be important in preventing mucosal injury in some patients with gastro-oesophageal reflux disease.

13.   The roles of active oxygen, lipid peroxidation, and the antioxidative defence mechanism in gastric mucosal injury induced by treatment with indomethacin in rats were investigated.

14.   Rainsford aslso noted, with transmission electron microscopy, that microvascular injury was present during gastric mucosal injury produced by indomethacin.

15.   Our present studies implicate active oxygen and lipid peroxidation in the pathogenesis of gastric mucosal injury induced by indomethacin.

16.   Cochran et al and Terano et al also reported that DMSO inhibited gastric mucosal injury induced by stress or ethanol.

17.   Also, lipid peroxide accumulation closely paralleled the development of gastric mucosal injury.

18.   The source of oxygen radicals in gastric mucosal injury induced by indomethacin in rats is not clear.

19.   These differences persisted when subgroups of patients were analysed according to Helicobacter pylori colonisation or degree of mucosal injury.

20.   Non-steroidal anti inflammatory drugs are associated with gastric mucosal injury that may result in peptic ulceration, upper gastrointestinal haemorrhage, and perforation.