11.   But Republican leaders said a major reduction is out of the question.

12.   Democratic opponents have argued that the amendment would bring about major reductions in federal social programs and state aid.

13.   Deutch declined to promise major spending reductions.

14.   Dr. Wilensky said she knew that some teaching hospitals had reported major reductions in revenue.

15.   For example, the final package appears to include a major reduction in estate taxes.

16.   If major reductions in the chemical threat produce even minor increases in the biological threat, it will be a bad trade.

17.   Investors are sure to receive a major reduction in the capital gains rates.

18.   Putin has also made clear that he wants a major mutual reduction in the American and Russian nuclear arsenals.

19.   Some states, however, reported major reductions in leaks, including Maine, Oklahoma, Wyoming and Washington.

20.   The agreement with Republican legislative leaders, however, would not lead to a major reduction in insurance rates.