11.   Both single large doses and fractionated doses of radiation have been shown to alter small intestinal motility in animals.

12.   Acute renal failure is not uncommon after aspirin overdose and large therapeutic doses of acetyl salicylic acid, choline salicylate, and sodium salicylate may cause acute tubular dysfunction.

13.   They were given three large doses of vitamin A over a week, and received vitamin A in all subsequent survey rounds.

14.   Large doses can result in blockages in blood supply to vital organs and breathing problems.

15.   Ms Christie said injecting tranquilisers in large doses could lead to dependency, anxiety, depression and loss of control.

16.   Although seriously crowded, Kiker is a good school, thanks to dedicated teachers and a large dose of parental involvement.

17.   Also, an animal study uses very large doses of a chemical that people are exposed to in only minute amounts.

18.   Although anthrax is said to be difficult to produce and spread in large doses, an enemy that managed to do so could inflict considerable damage.

19.   Analysts were in wholehearted agreement Monday, though they said Clinton must accept a large dose of responsibility for the failure to bring about change.

20.   And many of these drugs have damaging side effects in large doses, they said.