11.   These suggest that bleomycin distorts the DNA structure around its binding site to a form which is more readily cleaved by DNase I.

12.   This effect has been noted with natural DNA sequences and may be related to the ability of the antibiotic to unwind and extend the DNA helix.

13.   However these data were difficult to interpret rigorously because of the large number of overlapping binding sites.

14.   Since the catalytic cleavage of DNA by bleomycin occurs by a free radical mechanism it may not require a long residence time on its binding site.

15.   This sequence contains two bleomycin binding sites, which are probably too close to permit simultaneous binding of two ligand molecules.

16.   Single enzyme digestions yield fragments of identical lengths but with the position of the binding site circularly permuted with respect to the ends of the probes.

17.   Before internal docking can occur, a protein factor found in cytoplasm must first make its way to the internal binding site, Dasgupta said.

18.   Dr. Marian DiFiglia of Massachusetts General Hospital found that strings of glutamine are an important binding site for other regulatory proteins in a cell.

19.   Molecules that have a hydrogen atom at every available binding site.

20.   This binding site is an amino acid called cysteine, the function of which has puzzled hemoglobin researchers for decades.