111.   So scientists will have great difficulty figuring out what all those genes do and how they do it.

112.   Some say they have had great difficulty obtaining a letter from their employers.

113.   Some patients infected with both viruses find that their bodies have great difficulty tolerating many of the AIDS medications.

114.   States have great difficulty collecting money across state lines.

115.   Sources were often uncooperative, and Rossi had great difficulty confirming even the simplest facts.

116.   Still, some immigrants who are here illegally have had great difficulty proving where they worked and how much they earned.

117.   That year New York experienced a blizzard and exhibitors had great difficulty in getting to the Garden.

118.   The arrival of Smith to replace Lt. Gen. Sir Michael Rose has brought a sharp change of style, to which the Serbs have had great difficulty adapting.

119.   The crew of a Coast Guard helicopter had great difficulty finding people in the water at night in blinding snow and had to make several trips to rescue everyone.

120.   The great difficulty for board members, managers and shareholders is in recognizing when their use introduces more risk than it mitigates.