101.   Interpretation of the studies involving surgery is made very difficult by the problem of anatomical and functional changes caused by the surgical procedure itself.

102.   A reduced ampitude of the electrical control activity may result in a marked diminution of the signal to noise ratio making it difficult to extract the true dominant frequency.

103.   The sheer bulk of the material makes it difficult for them to do otherwise.

104.   The production of software should be depersonalised in the specific sense that the management system makes it difficult for individual producers to regard items of software as their own.

105.   This makes it difficult for her to accept the need to change.

106.   The simultaneous administration of two treatments makes it difficult to differentiate which induced the response.

107.   However they caution that the relatively small numbers of students in both studies makes it difficult to draw any firm generalisable conclusions.

108.   However the limited numbers of Access students who had completed higher education courses makes it difficult to draw any strong generalisable conclusions.

109.   In addition, the separation of data structures made it difficult to follow the interactions between the knowledge bases in the pursuit of a hypothesis.

110.   Some computer programs are marketed in a form that makes them difficult to copy.