1.   Although a vaccine can prevent the disease in someone who has been bitten by a rabid animal, it works only if given before symptoms begin.

2.   But by the end of five years, their symptoms began returning so that the two treatment groups were about equal.

3.   But once symptoms begin, the course is swift and relentless.

4.   If no preventive medicine is given and symptoms begin, the disease is fatal.

5.   Its symptoms begin like a cold, then progress to a deadly flooding of the lungs.

6.   Motor symptoms also begin early on and may include blurred vision, and difficulty swallowing.

7.   Once these symptoms have begun, treatment is usually ineffective.

8.   Once symptoms begin to develop, the disease is agonizing and incurable, and victims are invariably doomed to death.

9.   Public understanding is crucial, because TPA must be given within three hours after symptoms begin.

10.   Symptoms usually begin in middle age, starting with a stumbling gait that resembles being drunk, impaired thinking and depression.