1.   In Latin America and the Caribbean there had been a marked shift from homosexual to heterosexual transmission.

2.   Ascites should be treated with diuretics, although the elderly tolerate marked shifts in fluid and electrolytes less well than younger patients.

3.   And, like most business PACs, the individuals and firms affiliated with the gambling industry made a marked shift to the right.

4.   Her chiding of the mayor was a marked shift from her usual hands-off approach.

5.   His legacy is a marked shift in the political debate in the Netherlands, and maybe in Europe as well.

6.   It was a marked shift from January, when the shredding at Andersen exploded into public view.

7.   Newscasts saw a marked shift from overseas feature and background stories to hard news.

8.   Sunday, the scene outside the Lexington Armory signaled a marked shift in the miserable trajectory of the families of the missing.

9.   The advent of the strong jet stream signals a marked shift in the dry pattern of the past several weeks.

10.   The bills also reflect a marked shift in the legislature.