1.   Loss of viral replication by interferon can lead to a substantial regression of liver disease and probably prolonged survival.

2.   The cells destroy infected cells early, before they produce virus, thereby inhibiting viral replication, the company said.

3.   In patients with chronic hepatitis B virus infection active viral replication is usually associated with continuing inflammatory activity and progression of liver disease.

4.   Therefore we investigated the effect of intermittent interferon treatment on termination of herpatitis B viral replication, measured by HBeAg seroconversion and HBV-DNA clearance from serum.

5.   On these occasions routine haematological studies were performed and serum markers of viral replication and aspartate aminotransferase activity were measured.

6.   Prolonged therapy can further decrease HBV replication which may trigger the cullular immune response leading to the hepatocytotoxic reaction that eradicates viral replication.

7.   These data suggest that the risk of liver damage is greatest in patients with active viral replication before operation.

8.   These contain HBsAg and both nuclear and cytoplasmic HBcAg, signifying intense viral replication.