1.   It is also seen in some cases of renal disease especially where tubular necrosis or pyelonephritis exists.

2.   Some of these patients had acute tubular necrosis, which may be related to shock, bacteraemia hypovolaemia and drug nephrotoxicity.

3.   Pathological studies in the rat, however, suggest that tubular necrosis is transient despite continued dosing.

4.   Characteristics of the three patient groups are shown in table I.