1.   Another bioengineered skin substitute, Apligraf, made by Organogenesis of Canton, Mass., is made up of two layers of living skin cells.

2.   A Massachusetts firm called Organogenesis has brewed a more complete skin substitute, which includes both dermis and epidermis.

3.   --Organogenesis Inc. of Canton obtained a second approval for Apligraf, its human skin substitute, to treat diabetic foot ulcers.

4.   Several biotech companies are already racing to license skin substitutes that could revolutionize the treatment of burns and other serious wounds.