1.   A most significant departure for some one so senior to involve himself personally.

2.   Are there any significant departures from the use of the simple past tense?

3.   By estimating the expected number of each chromosome and comparing it with the observed number, any significant departures can be recorded.

4.   However, there are a number of significant departures from the earlier document.

5.   Nevertheless, this was not the simple procedure by which the most significant departure from union was effected.

6.   This marked a significant departure from previous foreign policy priorities which traditionally had made the Soviet Union the first place to be visited by a new Prime Minister.

7.   The Comintern suggestion that Communists should approach the official national committees of their respective Social Democratic Parties was, however, a significant departure.

8.   A more significant departure from standard lap siding is paneling with the look of weathered or painted cedar shakes.

9.   But experts say that exclusive benefits like deferred compensation are a significant departure from the way things used to be.

10.   But there was a significant departure.