1.   Brad Carlin of Edina, Minn., has been working six years to perfect a method for mastering March Madness.

2.   After perfecting the method for making clear bowling balls, Ebonite is considering what to add to the line.

3.   After some fits and starts, I think that I perfected the method.

4.   But fertility clinics that do in-vitro fertilization have vast experience in growing human embryos in the laboratory and have perfected the method.

5.   It also perfected a method of testing new merchandise by buying small quantities and watching sales in a few stores.

6.   Netgrocer, too, has struggled to perfect its methods and cost structure.

7.   Once safe methods are perfected, any gene, not just those that heal, theoretically could be inserted.

8.   Paris insists that the main purpose of the tests is to guarantee the accuracy of its new nuclear warheads and to perfect methods for future testing by computer simulation.

9.   Pushing too slowly, he noted, can get researchers mired in technical minutiae, while pushing too fast can waste opportunities to perfect the method.

10.   So even as some researchers are charging ahead with clinical trials, others are trying to perfect better methods of gene therapy.