1.   About half the patients develop gallstones.

2.   If the patient develops early overt congestive heart failure it is contraindicated, but do seriously consider it later.

3.   Most patients gradually develop a resistance to the drug.

4.   Some patients gradually develop a tolerance for the drug and need to be given a larger dose.

5.   Over time the patient could develop a resistance to the drug.

6.   Treatment was discontinued when patients developed evidence of cirrhosis or portal hypertension.

7.   Nine patients developed more than one stricture.