1.   Needle punctures should be avoided when possible, since they provoke inflammatory skin lesions.

2.   Ordinarily, getting the answer would have required a series of large needle punctures and a tissue analysis that would take one or two days.

3.   Rutan suffered cactus needle punctures to his face and body from his landing, and still has a sore ankle.

4.   Vials of vaccine are now made as single doses, requiring only one needle puncture, so that no preservatives need to be used.