1.   Several years ago it would have been incomprehensible for a rational scientist or physician to conclude that myocardial ischaemia might somehow act to protect the heart from necrosis.

2.   For example, the second coronary occlusion during the course of coronary angioplasty results in less evidence of myocardial ischaemia than the first.

3.   Rupture of atheromatous plaque leads to occlusive thrombosis that produces myocardial ischaemia and cell death leading to loss of ventricular function and possibly death.

4.   There was no ECG evidence of myocardial ischaemia despite symptoms of chest tingling and tightness.

5.   Overall, there is a small risk of myocardial ischaemia following sumatriptan-induced vasoconstriction.

6.   Concerns have also been expressed about the possibility of graft occlusions and increased myocardial ischaemia, especially in patients undergoing myocardial revascularisation.