1.   In small amounts it can act as a stimulant, in larger doses causing hyperactivity, headaches and insomnia.

2.   Some patients gradually develop a tolerance for the drug and need to be given a larger dose.

3.   Leonora longed for his company in much larger doses than he was able to spare, but had no intention of telling him so.

4.   Berglund said his team planned to test larger doses of metoprolol to determine whether they would produce more protection against plaque formation.

5.   Beutler countered that the company had an economic interest in promoting larger doses, making it slow to accept numerous studies showing the effectiveness of reduced dose regimens.

6.   But the larger doses may induce more side effects.

7.   He faced a life of increasingly larger doses of medication.

8.   Higher potency increases the likelihood of overdose, especially if people treat heroin like cocaine, which requires larger doses to get high.

9.   However, larger doses of estrogen have promoted blood clots in men and women who smoke, according to some studies.