1. In the case of the insulin receptor, the deglycosylated receptor retains its ability to bind to insulin. 2. But it is possible that its overexpression impairs the ability of the insulin receptor to activate cellular enzymes. 3. For instance, in diabetics the insulin receptor is usually OK but the signaling pathway inside the target cell is faulty, Tartaglia said. 4. It is taken into cells through an insulin receptor that sits on cell membranes. 5. The connection between weight and diabetes starts with insulin receptors on our cells, which enable insulin to do its work of spinning sugar into energy. 6. The insulin receptor is a protein embedded in the outer wall of human cells. 7. They scored a hit on the human gene that makes the insulin receptor. 8. Scientists already know the structure of the insulin receptor. 9. The difficulty is making a drug that gums up the IGF receptor but not the lookalike insulin receptor. |