1.   Many habitual drinkers of caffeine-containing beverages find that they must increase their dose to achieve the preferred degree of stimulation.

2.   Tolerance means that with regular use, you need to increase the dose to achieve the same effect.

3.   The sulphasalazine dose was increased in some of these patients but this increase always occurred after the flare started when the colitis had already been classified as moderately active.

4.   An addict gets high by taking the drug in a way that rapidly increases the dose reaching the brain.

5.   Giardiello said he thought it possible that increasing the dose would be effective.

6.   If they did not improve after four weeks, the dose was increased to four tablets.

7.   The lead article in the current New England Journal of Medicine goes even further, advising that everyone increase their dose.

8.   This may prompt the doctor to increase the dose or prescribe yet another drug to control the problem.

9.   With each treatment, the dose will be increased.

10.   Increasing doses of pain killers to huge levels for terminally ill patients is accepted palliative care practice.