1.   However, the combination of Herceptin and the sometimes toxic chemotherapy drug Adriamycin caused heart malfunction in some patients, though most continued on the combination.

2.   When this mechanism is defective, it can result in specific types of heart malfunctions.

3.   Doctors also said a heart malfunction appeared to be under control.

4.   Prince Claus, the husband of Queen Beatrix, has been diagnosed with a minor heart rhythm malfunction, the royal court said Tuesday.