1.   I accepted his resignation with great regret.

2.   It is with great regret that I must decline your offer.

3.   He expressed great regret and said that surgeons would attempt to reverse the operation.

4.   It was a great regret to me that our partnership was to come to an end.

5.   It is with great personal regret that I have come to this conclusion.

6.   Don Pintabona, the chef of TriBeCa Grill, had a fling with escolar early on but also gave it up with great regret.

7.   His great regret, though, is that he did not become a poet.

8.   His great regret was that he never competed in the Olympics.

9.   Spivey said he had one great regret.