1.   This study measured the values of cyclic nucleotides and adenylate and guanylate cyclase activities in duodenal mucosa homogenates to verify if they played a part in coeliac disease.

2.   In this study we measured adenylate and guanylate cyclase activities and cyclic nucleotide values in the biopsy specimens of duodenal mucosa from patients with untreated and treated coeliac disease.

3.   Each of these abnormalities will increase the exposure of the duodenal mucosa to acid and thus explain its ulceration.

4.   As a result, the inflamed duodenal mucosa may then become susceptible to acid and this may ultimately lead to ulceration.

5.   The question has been raised whether these changes result in restoration of the duodenal mucosa and disappearance of gastric epithelium from the duodenal bulb.

6.   Gastroscopy showed a nodular gastric mucosa with apthous ulceration and superficially normal duodenal mucosa.

7.   This may partly explain the lack of change in the appearance of the duodenal mucosa on serial biopsy in this condition.

8.   In the rat, this negative feedback control is mediated by cholecystokinin, which is probably released by protease sensitive proteins from either duodenal mucosa or pancreatic juice.