1.   In the most severe cases, the disease can lead to blindness.

2.   The disease leads to debility but rarely kills.

3.   Epigastric pain is uncommon and concurrent peptic ulcer disease may lead to an incorrect diagnosis.

4.   The disease leads to convuclsions and an agonising death.

5.   And no doubt the disease could lead to political instability.

6.   Diseases can lead to a veritable rainbow of nails.

7.   In a few cases, untreated disease can lead to severe, chronic and disabling illness, according to the Centers for Disease Control.

8.   In some cases, the disease can lead to kidney and liver failure.

9.   Longstanding coronary artery disease had led to a condition known as ischemic cardiomyopathy in which heart muscle dies from oxygen starvation.

10.   Mad cow disease could lead to the first use of a new state law that makes it illegal to say bad and untruthful things about perishable food products.