1.   These examples illustrate the central problem of characterising chromosomal deletions - how do you know when you have identified the target gene?

2.   Loss of tumour suppressor function requires inactivation of both alleles, usually by chromosomal deletion or point mutation, or both.

3.   The presence of other chromosomal deletions in colorectal cancer suggests that several more tumour suppressor genes have yet to be identified.

4.   These examples illustrate the central problem of characterising chromosomal deletions -- how do you know when you have identified the target gene?

5.   The method also made it possible to detect chromosomal deletions in the urine cells of people diagnosed with cancer.