1. The allele frequency of the small fragment was significantly higher in patients with gastric body ulcer than in controls and in patients with gastric angular or antral ulcer. 2. The genotypes which possessed the small fragment was significantly more frequent in patients with gastric body ulcer than in controls and in patients with gastric angular or antral ulcer. 3. In order to gain a better appreciation of the genotypic risk, the relative risk of gastric body ulcer associated with the genotypes was estimated. 4. Serum PGC levels were significantly higher in patients with body ulcer and in patients with angular or antral ulcer than in controls. 5. Our data indicate an association between the genetic polymorphism at the PGC gene locus and gastric body ulcer. 6. The allele frequency of the small fragment of the PGC RFLP in patients with gastric body ulcer was significantly hgiher than that in controls. 7. The genotypes containing the small fragment were significantly more frequent in patients with gastric body ulcer than in controls and in patients with gastric angular or antral ulcer. 8. These results suggest that the PGC RFLP is a useful subclinical marker of the genetic predisposition to gastric body ulcer. 9. The allele frequency of the small fragment of the PGC RFLP was significantly higher in patients with gastric body ulcer than in patients with gastric angular or antral ulcer. |