1. These contradictory effects can be explained by probing deeper into the subject of adenosine receptors. 2. These results suggest that caffeine indirectly affects many neurotransmitter systems through its direct effects on adenosine receptors. 3. Two thumbtack-size patches of neurons located on the brain stem are particularly loaded with adenosine receptors. 4. Although adenosine receptors couple to several signalling systems in myocytes we now believe that protein kinase C is the important one for preconditioning. 5. Repopulation of adenosine receptors during the second occlusion can then result in phosphorylation of proteins early in the ischaemic period and these mediate the protection. 6. In the new study, scientists created mice that lacked one of the four kinds of adenosine receptors. |