71.   Using endoscopic biopsy we were able to compare patients with different diseases and control subjects with gastric mucosa histologically free of significant alterations.

72.   In particular, for the purposes of this study, it can measure the S phase duration of crypt cells in gastric mucosa.

73.   Gastric mucosa is nevertheless a structured, spatially organised tissue of considerable clinical and biological importance.

74.   A opportunity arose from a primary study of proliferation in gastric malignancy to investigate BrdUrd labelled gastric mucosa.

75.   This would be difficult to test in gastric mucosa, because crpt anatomy varies throughout the stomach, and normal anatomical variation might mask any tumour associated changes.

76.   With regard to man, Lipkin et al studied tritiated thymidine labelling in the gastric mucosa of a patient with oesophageal malignancy and a gastrostomy in serial biopsies.

77.   Our data describe a technique which has allowed detailed study of the proliferation compartment of human gastric mucosa, about which little has been published.

78.   These findings suggest that the rearrangement of the PGC gene may reflect the atrophic change of gastric mucosa.

79.   There have also been studies to suggest that unburned tobacco in the form of snuff or chewing tobacco has a carcinogenic effect on gastric mucosa.

80.   Bismuth has, however, effects on the gastric mucosa apart from that on H pylori.