61.   Serono says higher doses of its drug Rebif are more effective than Avonex although the FDA disagrees.

62.   Slightly higher doses can lead to euphoria or intoxication.

63.   Steroids can be injected or taken orally, although the latter requires much higher doses and therefore more potential health hazards.

64.   The aim is to allow the patient to tolerate much higher doses than are now possible.

65.   The Chiron implant is designed to deliver a much higher dose to the key site of infection, without the same risk of side effects.

66.   The company is working to develop a second generation of the Leptin molecule that will be more tolerable at the higher doses.

67.   The drug is safe when used according to FDA guidelines, although doctors sometime prescribe it in higher doses for longer periods than recommended, they said.

68.   The European trial used a different version of Activase, a higher dose drug called Actilyse marketed by German drugmaker Boehringer Ingelheim.

69.   The company uses technology to reformulate existing drug compounds so a drug can be administered at higher doses without debilitating side effects.

70.   The FDA also had some concerns about animal studies that showed other heart and liver problems at doses higher than what patients would receive, the company said.