51.   Condra said the study was done with patients who took a lower dose than current studies use.

52.   --Enrollment of new patients in the experiments using higher doses despite adverse reactions experienced by earlier patients at lower doses.

53.   Lower doses ingested over a period of time can cause mental retardation.

54.   Nobody really knows how lower doses delivered over decades will affect humans.

55.   One attempt at a lower dose failed.

56.   The agency also is debating how to make manufacturers determine the lowest effective dose of each drug, because lower doses should mean less risk.

57.   The FDA decision does not affect dozens of other gene therapy experiments that use lower doses of adenoviruses or that inject them into some organ other than the liver.

58.   The lower dose had no significant effect on testosterone levels, though levels of the female hormone estrogen increased substantially with both doses.

59.   The lower dose worked better.

60.   The study of the advanced patients may resume within weeks with new patients on lower doses.