41.   The new rule had taken a broad sweep, covering many industries.

42.   The new rules have not taken hold everywhere yet.

43.   The new rules take effect today.

44.   The new rules will take effect in mid-April.

45.   The proposed rules could take effect as early as this year.

46.   The repeatedly delayed rules will take effect only next month.

47.   The rule took effect this month.

48.   The rules take effect immediately, although the FDA said it would continue to monitor their effects to see whether any adjustments were needed in the months ahead.

49.   The rules take effect immediately, although the health-care industry will receive two years to come fully into compliance.

50.   The rules take effect starting next year.