41.   A major obstacle was that they were dealing with an unstable substance that often lost activity when concentrated.

42.   A memorial with no flying flag is a major obstacle for some Republicans.

43.   A major obstacle comes Saturday.

44.   A major obstacle is the current American posture.

45.   A major obstacle, however, was eliminated when Prudential withdrew from the fight.

46.   A major potential obstacle to such a finding is the view of the states that filed their own parallel lawsuit and have been reluctant to join the agreement.

47.   A major obstacle in revamping computer systems to handle the new millennium is the tremendous resources necessary to get the job done.

48.   A major obstacle is history.

49.   A major obstacle is the Coliseum floor, which is designed for NFL and college football, and which already hosts the Raiders and USC.

50.   All the top minor-league prospects have major obstacles to overcome.