41.   Opponents are concerned that direct-to-consumer advertising can lead patients to believe that a minor difference between drugs is a major therapeutic advance.

42.   Patrick said his department made major advances in civil rights enforcement of voting, education, employment, police misconduct and housing cases.

43.   Scientists are releasing reports on Friday of two major advances in the concept of using embryonic cells to regenerate human tissues.

44.   She made no major advances, but she kept the house on track.

45.   So even those who see the equipment as a major advance in rescue technology raise some concerns.

46.   The article also referred incorrectly to a major earlier advance cited by Dr. Patrick Borgen as comparable in importance.

47.   The development of Xyrem, made by Orphan Medical Inc., of Minnetonka, Minn., is just one of several major advances in the understanding and treating narcolepsy.

48.   The major advances of democracy, science, universal education and the free enterprise system grew out of cultures fortified by Christian hope.

49.   The mechanism of drug delivery is a major advance.

50.   The huge screen is considered a major advance over the poster-board placards traditionally used by lawyers to display evidence and exhibits.