41.   Extensive and deep biopsy specimens were taken, the gastric mucosa felt infiltrated at biopsy.

42.   Histological examination of these areas at this time confirmed a chronic gastritis and atrophic gastric mucosa.

43.   Gastroscopy showed a nodular gastric mucosa with apthous ulceration and superficially normal duodenal mucosa.

44.   Murakami et al showed that ammonia produced by the administration of urea plus urease to rats can cause microscopic injury to their gastric mucosa.

45.   The total area of gastric erosions and concentration of lipif peroxidesin the gastric mucosa increased with time after administration of indomethacin.

46.   Treatments with superoxide dismutase and catalase inhibited the increases in gastric mucosal erosions and lipid peroxides in the gastric mucosa, and the reduction of serum -tocopherol.

47.   The present study was undertaken in rats to measure changes in lipid peroxides and antioxidants in serum samples and gastric mucosa after administration of indomethacin.

48.   The concentration of lipid peroxides in the gastric mucosa was also measured.

49.   The activity of glutathione peroxidase in the gastric mucosa was assayed spectrophotometrically by the method of Gunzler et al with t -butyl hydroperoxidase as the substrate.

50.   Intragastric administration of indomethacin did not affect the activities of SOD in the gastric mucosa at three or six hours after indomethacin.