21.   Federal health officials said they hoped that this would spell the end of the beta carotene fad.

22.   For Purity, the sale spells the end of the Purity name.

23.   For years, financial analysts predicted that the savings and loan crisis would spell the end of Southern California-based industry.

24.   For Connor Toole and his neighbors, cold evening temperatures spelled the end of the mosquito threat.

25.   He said the baseball-only stadium will undoubtedly lead to higher rents, spelling the end of his business.

26.   He took the visitors for avenging divinities and feared that their appearance spelled the end of his civilization.

27.   His death spelled the end of the Rurik dynasty and effectively cleared the way for the ascendance of the Romanovs.

28.   If the Israeli army remains free to act in this way, it will spell the end of the PA.

29.   If this does not exactly spell the end of everything, it will effectively be the end of the universe as it is currently understood.

30.   In a cruel twist, though, the Prowler is equipped with a technology that could spell the end of the true manual transmission.