21.   The necessity for using very high doses of reagents, however, to detect in vitro phosphorylation of membranes, is well recognised.

22.   For example, stem cells are particularly sensitive to irradiation and most are killed after high sublethal doses.

23.   Mesalazine has structural similarities to aspirin and phenacetin and is nephrotoxic when given intravenously in high doses to rats.

24.   In addition, freedom from sulphapyridine related side effects allows high dose treatment, further increasing the potential for dose related nephrotoxicity.

25.   Moreover, high dose para-aminosalicylic acid was, for many years, used in the treatment of tuberculosis yet nephrotoxic reactions were uncommon.

26.   In the rat, very high single doses of intravenous mesalazine cause acute tubular and papillary necrosis.

27.   Animal experiments suggest that a high dose is required, and the fact that there is no person-to-person spread supports this view.

28.   Others go beyond restriction to more dangerous behaviours, such as selfinduced vomiting, purgation with high doses of laxatives, and the misuse of diuretics and appetite suppressants.

29.   At high doses, it is lethal.

30.   If workers had been in the vicinity, they would have received high doses of radiation.