21.   In amyloidosis, abnormal proteins collect throughout the body, causing clumps that can wreak havoc with the normal function of many organs.

22.   Instead of the soft, doughnut-shaped, normal hemoglobin, the abnormal protein often forms into a distinctive sickle shape with a sharp point.

23.   Mad cow disease and CJD are caused by infectious agents called prions, which are made up chiefly or totally of abnormal proteins.

24.   Mad cow disease is caused by an abnormal protein, called a prion, which can cause changes in normal proteins and result in deep lesions in the brain.

25.   Many drugs target single abnormal proteins.

26.   Researchers chose CML because they knew about the abnormal chromosome and its abnormal protein.

27.   Tanaka also downplayed a recent study that said abnormal proteins, or prions, stored in animal tissue could be a threat.

28.   Tanaka also said a recent study indicating a possible threat from abnormal proteins, or prions, stored in animal tissue was inconclusive.

29.   That confirms the idea that the disease, called fatal familial insomnia, belongs to a small group of neurological disorders caused by an abnormal protein called a prion.