11.   The effects of bile on small bowel motility were studied in isolated, perfused rabbit terminal ileum.

12.   The ileal brake was initially defined by showing that the infusion of fat into the terminal ileum in man slowed both gastric emptying and intestinal transit.

13.   PYY is found in high concentrations in the terminal ileum and is released after meals.

14.   We used a model of isolated, perfused rabbit terminal ileum to characterise the effects of luminal bile salts on intestinal motility.

15.   Thus, luminal infusion of rabbit bile and TDCA inhibited motor activity in isolated segments of rabbit terminal ileum.

16.   These studies showed that a humoral agent present in the venous effluent during luminal administration of bile, inhibited motor activity in isolated segments of terminal ileum.

17.   This study showed that luminal infusion of bile and the bile acid TDCA inhibited carbachol stimulated motor activity in isolated segments of rabbit terminal ileum.

18.   This suggested that bile inhibition of ileal motor activity was mediated by a humoral agent from the terminal ileum present in the venous effluent.

19.   These findings suggest that postprandial increases in bile salt concentrations in the terminal ileum may play a role in the inhibition of ileal motility.

20.   Other regulatory peptides in the terminal ileum may mediate bile inhibition of ileal motility.