11.   They ran off at the first sign of trouble.

12.   Will they panic at the first sign of trouble?

13.   The first signs of the disease can easily be overlooked.

14.   The first signs of economic decline became visible.

15.   While the current generation of chip-based handhelds continue to sell well, the first signs of a major shift towards handheld CD media are becoming apparent.

16.   Access to this flood of information about ourselves will eventually transform medical practice, and the first signs of this are already apparent.

17.   The old nomes grumbled among themselves, and scanned the sky anxiously for the first signs of robins or reindeer.

18.   The first sign was slogans daubed on the wall of a kuttub, a religious school where small children went for their first instruction in the Koran.

19.   Fistula formation -- for example to the trachea -- may then be the first sign of the true nature of the disease.

20.   In Europe, performance in France and Spain remains unsatisfactory, although it is now showing the first signs of improvement.