11.   Estrogen supplements are taken by millions of women to ease hot flashes, brittle bones and other symptoms of menopause.

12.   Ipriflavone is not FDA approved, but has been marketed as a natural alternative without the side effects of estrogen supplements.

13.   Limacher said that until recently, she routinely recommended estrogen supplements for older women with heart disease.

14.   Many women take estrogen supplements for a few years to ease the miseries of menopause.

15.   Millions of women take estrogen supplements to ease hot flashes and other symptoms of menopause and to protect themselves against osteoporosis.

16.   Millions of women take estrogen supplements to replace the hormones their bodies stop making at menopause.

17.   Recent studies have called into question whether estrogen supplements really do lower the risk of heart disease, as doctors have long believed.

18.   Some previous studies have linked estrogen supplements, either alone or combined with progestin, with higher rates of breast cancer.

19.   The study is the latest to raise questions about the common practice of prescribing estrogen hormone supplements for women after menopause.

20.   Women take estrogen supplements after menopause to suppress symptoms like hot flashes and lower the risks of osteoporosis and heart disease.